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1

Mitochondria-Targeted Antioxidants in the Treatment of Disease

Robin A.J. Smith, Victoria J. Adlam, Frances H. Blaikie, Abdul-Rahman B. Manas, Carolyn M. Porteous, Andrew M. James, Meredith F. Ross, Angela Logan, Helena M. Cochemé, Jan Trnka, Tracy A. Prime, Irin

Journal:

Annals of the New York Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 144 KB

english, 2008

2

Mitochondrial targeting of quinones: Therapeutic implications

Helena M. Cochemé, Geoffrey F. Kelso, Andrew M. James, Meredith F. Ross, Jan Trnka, Thabo Mahendiran, Jordi Asin-Cayuela, Frances H. Blaikie, Abdul-Rahman B. Manas, Carolyn M. Porteous, Victoria J. Ad

Journal:

Year:

2007

Language:

english

File:

PDF, 237 KB

english, 2007

3

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

Carolyn M. Porteous, Angela Logan, Cameron Evans, Elizabeth C. Ledgerwood, David K. Menon, Franklin Aigbirhio, Robin A.J. Smith, Michael P. Murphy

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

4

Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

Michael A. Packer, Carolyn M. Porteous, Michael P. Murphy

Journal:

Year:

1996

Language:

english

File:

PDF, 476 KB

english, 1996

5

Proteomic Analysis of Liver from Human Lipoprotein(a) Transgenic Mice Shows an Oxidative Stress and Lipid Export Response

McCormick, Sally, Porteous, Carolyn, Sharma, Monika, Jones, Greg, Legge, Michael, Kleffmann, Torsten, Rodger, Euan

Journal:

Atherosclerosis Supplements

Year:

2018

Language:

english

File:

PDF, 44 KB

english, 2018

6

Proteomic Analysis of Liver from Human Lipoprotein(a) Transgenic Mice Shows an Oxidative Stress and Lipid Export Response

Rodger, Euan J., Porteous, Carolyn M., Jones, Gregory T., Legge, Michael, Kleffmann, Torsten, McCormick, Sally P. A.

Journal:

BioMed Research International

Year:

2018

Language:

english

File:

PDF, 2.80 MB

english, 2018

7

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

Jared L. Scarlett, Michael A. Packer, Carolyn M. Porteous, Michael P. Murphy

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.04 MB

english, 1996

8

P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain

Porteous, Carolyn M., Menon, David K., Aigbirhio, Franklin I., Smith, Robin A.J., Murphy, Michael P.

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2013

Language:

english

File:

PDF, 444 KB

english, 2013

9

Accumulation of lipophilic dications by mitochondria and cells

Ross, Meredith F., Da Ros, Tatiana, Blaikie, Frances H., Prime, Tracy A., Porteous, Carolyn M., Severina, Inna I., Skulachev, Vladimir P., Kjaergaard, Henrik G., Smith, Robin A. J., Murphy, Michael P.

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 572 KB

english, 2006

10

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Ross, Meredith F., Prime, Tracy A., Abakumova, Irina, James, Andrew M., Porteous, Carolyn M., Smith, Robin A. J., Murphy, Michael P.

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 780 KB

english, 2008

11

Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids

Sharma, Monika, Von Zychlinski-Kleffmann, Anne, Porteous, Carolyn M., Jones, Gregory T., Williams, Michael J. A., McCormick, Sally P. A.

Journal:

The Journal of Lipid Research

Year:

2015

Language:

english

File:

PDF, 2.54 MB

english, 2015

12

Selective targeting of an antioxidant to mitochondria

Robin A. J. Smith, Carolyn M. Porteous, Carolyn V. Coulter, Michael P. Murphy

Journal:

Year:

1999

Language:

english

File:

PDF, 743 KB

english, 1999

13

Ribose-cysteine protects against the development of atherosclerosis in apoE-deficient mice

Kader, Tanjina, Porteous, Carolyn M., Jones, Gregory T., Dickerhof, Nina, Narayana, Vinod K., Tull, Dedreia, Taraknath, Sreya, McCormick, Sally P. A., Bader, Michael

Journal:

Year:

2020

Language:

english

File:

PDF, 1.98 MB

english, 2020

14

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Helena M. Cochemé, Caroline Quin, Stephen J. McQuaker, Filipe Cabreiro, Angela Logan, Tracy A. Prime, Irina Abakumova, Jigna V. Patel, Ian M. Fearnley, Andrew M. James, Carolyn M. Porteous, Robin A.J.

Journal:

Cell Metabolism

Year:

2011

Language:

english

File:

PDF, 753 KB

english, 2011

15

Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice

Kader, Tanjina, Porteous, Carolyn M., Williams, Michael J.A., Gieseg, Steven P., McCormick, Sally P.A.

Journal:

Atherosclerosis

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

16

Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants

GEOFFREY F. KELSO, CAROLYN M. PORTEOUS, GILLIAN HUGHES, ELIZABETH C. LEDGERWOOD, ALISON M. GANE, ROBIN A. J. SMITH, MICHAEL P. MURPHY

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 9.90 MB

english, 2002

17

A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic

Geoffrey F. Kelso, Andrej Maroz, Helena M. Cochemé, Angela Logan, Tracy A. Prime, Alexander V. Peskin, Christine C. Winterbourn, Andrew M. James, Meredith F. Ross, Sally Brooker, Carolyn M. Porteous,

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 571 KB

english, 2012

18

Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion

William K. Porteous, Andrew M. James, Philip W. Sheard, Carolyn M. Porteous, Michael A. Packer, Serena J. Hyslop, Julian V. Melton, Cheng-Yoong Pang, Yau-Huei Wei, Michael P. Murphy

Journal:

Year:

1998

Language:

english

File:

PDF, 734 KB

english, 1998

19

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

Cochemé, Helena M, Logan, Angela, Prime, Tracy A, Abakumova, Irina, Quin, Caroline, McQuaker, Stephen J, Patel, Jigna V, Fearnley, Ian M, James, Andrew M, Porteous, Carolyn M

Journal:

Nature Protocols

Year:

2012

Language:

english

File:

PDF, 788 KB

english, 2012

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